Thymidine kinase

BE0000458ProteinHHV-1TK

Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. It is acted on by 16 drugs in DrugBank.

Gene name
TK
UniProtKB entry
Q9QNF7Swiss-Prot
Residues / weight
376 residues · 40,896 Da
Also known as
2.7.1.21 · UL23

Resolves to

Protein
UniProtQ9QNF7UniProt nameKITH_HHV1
Gene
GenBank8100965
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thymidine kinase, how selective are they, and which programs against it are still in active trials?

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