Idoxuridine is a pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis. An analog of deoxyuridine that inhibits viral DNA synthesis.
- Mechanism
- Curator reviewed
Idoxuridine acts as an antiviral agent by inhibiting viral replication by substituting itself for thymidine in viral DNA. This in turn inhibits thymidylate phosphorylase and viral DNA polymerases from properly functioning. The effect of Idoxuridine results in the inability of the virus to reproduce or to infect/destroy tissue.
- Primary indication
- For use in keratoconjunctivitis and keratitis caused by herpes simplex virus.Curator reviewed · 3 structured indications
- Formula / weight
- C9H11IN2O5 · 354.0985 g/mol (avg)
- First approval
- Canada, 2005 · United States, 1963
- Also known as
- 5-Iododeoxyuridine · Idoxuridin · Iododeoxyridine · Iodoxuridine
- Code names
- ALLERGAN-211 · NSC-39661 · SK&F 14287
Resolves to
Structure
InChIKey
XQFRJNBWHJMXHO-RRKCRQDMSA-NSMILESOC[C@H]1O[C@H](C[C@@H]1O)N1C=C(I)C(=O)NC1=OWhat you can answer from here — as of September 12, 2026
3Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Idoxuridine, and which of those have an active Phase 3 trial?
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