NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

BE0000493ProteinHumansNDUFS1

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30879903, PubMed:31557978). It is acted on by 3 drugs in DrugBank.

Gene name
NDUFS1
UniProtKB entry
P28331Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
727 residues · 79,467 Da
Also known as
7.1.1.2 · CI-75kD · Complex I-75kD

Resolves to

Protein
UniProtP28331UniProt nameNDUS1_HUMAN
Gene
HGNCHGNC:7707NCBI Gene4719GenBank38079GeneCardsNDUFS1
Pharmacology
KEGGhsa:4719
Structure
PDB5XTBPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial, how selective are they, and which programs against it are still in active trials?

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