Epithelial sodium channel subunit delta

BE0000495ProteinHumansSCNN1D

Potential alternative pore-forming subunit of the epithelial sodium channel (ENaC), capable of replacing the alpha/SCNN1A subunit, creating a more active channel with distinct properties (PubMed:16423824, PubMed:19520916, PubMed:22505667). It is acted on by 3 drugs in DrugBank.

Gene name
SCNN1D
UniProtKB entry
P51172Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
802 residues · 87,849 Da
Also known as
Amiloride-sensitive sodium channel subunit delta · Delta-ENaC · Delta-NaCH · DNACH · ENaCD

Resolves to

Protein
UniProtP51172UniProt nameSCNND_HUMAN
Gene
HGNCHGNC:10601NCBI Gene6339GenBank1066457GeneCardsSCNN1D
Pharmacology
KEGGhsa:6339
Structure
PDB9BLR
Drugs

What you can answer from here — as of February 11, 2025

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Epithelial sodium channel subunit delta, how selective are they, and which programs against it are still in active trials?

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