Choline O-acetyltransferase

BE0000519ProteinHumansCHAT

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. It is acted on by 5 drugs in DrugBank.

Gene name
CHAT
UniProtKB entry
P28329Swiss-Prot
Residues / weight
748 residues · 82,535 Da
Also known as
2.3.1.6 · ChAT · CHOACTase · Choline acetylase

Resolves to

Protein
UniProtP28329UniProt nameCLAT_HUMAN
Gene
HGNCHGNC:1912NCBI Gene1103GenBank301096GeneCardsCHAT
Pharmacology
KEGGhsa:1103
Structure
PDB2FY2PDB2FY3PDB2FY4
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
23+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Choline O-acetyltransferase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In