All-trans-retinol dehydrogenase [NAD(+)] ADH7

BE0000522ProteinHumansADH7

Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). It is acted on by 6 drugs in DrugBank.

Gene name
ADH7
UniProtKB entry
P40394Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
386 residues · 41,481 Da
Also known as
1.1.1.105 · Alcohol dehydrogenase class 4 mu/sigma chain · Alcohol dehydrogenase class IV mu/sigma chain · Gastric alcohol dehydrogenase · Omega-hydroxydecanoate dehydrogenase ADH7

Resolves to

Protein
UniProtP40394UniProt nameADH7_HUMAN
Gene
HGNCHGNC:256NCBI Gene131GenBank516618GeneCardsADH7
Pharmacology
KEGGhsa:131
Structure
PDB1AGNPDB1D1SPDB1D1T
Drugs

What you can answer from here — as of September 03, 2024

6DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on All-trans-retinol dehydrogenase [NAD(+)] ADH7, how selective are they, and which programs against it are still in active trials?

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