3-oxo-5-alpha-steroid 4-dehydrogenase 1

BE0000539ProteinHumansSRD5A1

Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed:2339109, PubMed:23685396). It is acted on by 19 drugs in DrugBank.

Gene name
SRD5A1
UniProtKB entry
P18405Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
259 residues · 29,458 Da
Also known as
1.3.1.22 · S5AR 1 · SR type 1 · Steroid 5-alpha-reductase 1

Resolves to

Protein
UniProtP18405UniProt nameS5A1_HUMAN
Gene
HGNCHGNC:11284NCBI Gene6715GenBank177767GeneCardsSRD5A1
Pharmacology
KEGGhsa:6715
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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36GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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46+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-oxo-5-alpha-steroid 4-dehydrogenase 1, how selective are they, and which programs against it are still in active trials?

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