NAV

Polyestradiol phosphate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Polyestradiol phosphate
DrugBank Accession Number
DB09369
Background

Polymeric phosphoric acid ester of estradiol.

Type
Small Molecule
Groups
Approved
Synonyms
  • (17-beta)-Estra-1,3,5(10)-triene-3,17-diol polymer with phosphoric acid
  • Estradiol phosphate polymer
  • Fosfato de poliestradiol
  • Oestradiol phosphate polymer
  • Phosphate de polyestradiol
  • Poly(estradiol phosphate)
  • Polyestradiol phosphate
  • Polyestradioli phosphas
External IDs
  • LEO 114
  • LEO-114

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
AEstrogen receptor alpha
agonist
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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interactions in your software
AbciximabPolyestradiol phosphate may decrease the anticoagulant activities of Abciximab.
AceclofenacAceclofenac may increase the thrombogenic activities of Polyestradiol phosphate.
AcenocoumarolPolyestradiol phosphate may decrease the anticoagulant activities of Acenocoumarol.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Polyestradiol phosphate.
AdalimumabPolyestradiol phosphate may increase the thrombogenic activities of Adalimumab.
AducanumabPolyestradiol phosphate may increase the thrombogenic activities of Aducanumab.
AlemtuzumabPolyestradiol phosphate may increase the thrombogenic activities of Alemtuzumab.
AlirocumabPolyestradiol phosphate may increase the thrombogenic activities of Alirocumab.
AlteplasePolyestradiol phosphate may decrease the anticoagulant activities of Alteplase.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Polyestradiol phosphate.
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Food Interactions
Not Available

Products

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International/Other Brands
Estradurin

Categories

ATC Codes
L02AA02 — Polyestradiol phosphate
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
P14877CDX2
CAS number
28014-46-2

References

General References
Not Available
KEGG Drug
D07434
RxNav
34120
ChEMBL
CHEMBL1201477
Wikipedia
Polyestradiol_phosphate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Targets

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Details1. Estrogen receptor alpha
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissu...
Gene Name
ESR1
Uniprot ID
P03372
Uniprot Name
Estrogen receptor
Molecular Weight
66215.45 Da
References
  1. Mikkola A, Ruutu M, Aro J, Rannikko S, Salo J: The role of parenteral polyestradiol phosphate in the treatment of advanced prostatic cancer on the threshold of the new millennium. Ann Chir Gynaecol. 1999;88(1):18-21. [Article]

Drug created at November 30, 2015 19:10 / Updated at February 21, 2021 18:52