Glyceraldehyde-3-phosphate dehydrogenase

BE0000542ProteinHumansGAPDH

Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis (PubMed:11724794, PubMed:3170585). It is acted on by 12 drugs in DrugBank.

Gene name
GAPDH
UniProtKB entry
P04406Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
335 residues · 36,053 Da
Also known as
1.2.1.12 · GAPD · GAPDH · Peptidyl-cysteine S-nitrosylase GAPDH

Resolves to

Protein
UniProtP04406UniProt nameG3P_HUMAN
Gene
HGNCHGNC:4141NCBI Gene2597GenBank31645GeneCardsGAPDH
Pharmacology
KEGGhsa:2597
Structure
PDB1U8FPDB1ZNQPDB3GPD
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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61+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glyceraldehyde-3-phosphate dehydrogenase, how selective are they, and which programs against it are still in active trials?

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