Propionyl-CoA carboxylase beta chain, mitochondrial

BE0000544ProteinHumansPCCB

This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other... It is acted on by 3 drugs in DrugBank.

Gene name
PCCB
UniProtKB entry
P05166Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
539 residues · 58,215 Da
Also known as
6.4.1.3 · PCCase subunit beta · Propanoyl-CoA:carbon dioxide ligase subunit beta

Resolves to

Protein
UniProtP05166UniProt namePCCB_HUMAN
Gene
HGNCHGNC:8654NCBI Gene5096GenBank312812GeneCardsPCCB
Pharmacology
KEGGhsa:5096
Structure
PDB7YBUPDB8XL3PDB8XL4
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Propionyl-CoA carboxylase beta chain, mitochondrial, how selective are they, and which programs against it are still in active trials?

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