Sterol 26-hydroxylase, mitochondrial

BE0000549ProteinHumansCYP27A1

Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. It is acted on by 6 drugs in DrugBank.

Gene name
CYP27A1
UniProtKB entry
Q02318Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
531 residues · 60,234 Da
Also known as
1.14.15.15 · 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase · CYP27 · Cytochrome P-450C27/25 · Cytochrome P450 27

Resolves to

Protein
UniProtQ02318UniProt nameCP27A_HUMAN
Gene
HGNCHGNC:2605NCBI Gene1593GenBank181292GeneCardsCYP27A1
Pharmacology
IUPHAR/GtoPdb1369KEGGhsa:1593
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sterol 26-hydroxylase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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