Chenodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis. Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586).
- Mechanism
- Curator reviewed
Chenodiol suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing the latter and its metabolite, deoxycholic acid in an expanded bile acid pool. These actions contribute to biliary cholesterol desaturation and gradual dissolution of radiolucent cholesterol gallstones in the presence of a gall-bladder visualized by oral cholecystography. Bile acids may also bind the the bile acid receptor (FXR) which regulates the synthesis and transport of bile acids.
- Primary indication
- Chenodiol is indicated for patients with radiolucent stones in well opacifying gallbladders, in whom elective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age.Curator reviewed · 3 structured indications
- Formula / weight
- C24H40O4 · 392.572 g/mol (avg)
- First approval
- United States, 2009 · European Union, 2020
- Also known as
- Anthropodeoxycholic acid · Anthropodesoxycholic acid · CDCA · Chenic acid · Chenocholic acid
- Brand names
Resolves to
RUDATBOHQWOJDD-BSWAIDMHSA-NSMILES[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Chenodeoxycholic acid, and which of those have an active Phase 3 trial?
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