Calcium-activated potassium channel subunit alpha-1

BE0000553ProteinHumansKCNMA1

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:14523450, PubMed:29330545, PubMed:31152168). It is acted on by 14 drugs in DrugBank.

Gene name
KCNMA1
UniProtKB entry
Q12791Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,236 residues · 137,558 Da
Also known as
BK channel · BKCA alpha · Calcium-activated potassium channel, subfamily M subunit alpha-1 · hSlo · K(VCA)alpha

Resolves to

Protein
UniProtQ12791UniProt nameKCMA1_HUMAN
Gene
HGNCHGNC:6284NCBI Gene3778GenBank537439GeneCardsKCNMA1
Pharmacology
IUPHAR/GtoPdb380KEGGhsa:3778
Structure
PDB10ADPDB2K44PDB3MT5
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calcium-activated potassium channel subunit alpha-1, how selective are they, and which programs against it are still in active trials?

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