Beta-ketoacyl-[acyl-carrier-protein] synthase III

BE0000558ProteinEscherichia coli (strain K12)fabH

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is acted on by 6 drugs in DrugBank.

Gene name
fabH
UniProtKB entry
P0A6R0Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
317 residues · 33,515 Da
Also known as
2.3.1.180 · 3-oxoacyl-[acyl-carrier-protein] synthase 3 · 3-oxoacyl-[acyl-carrier-protein] synthase III · Beta-ketoacyl-ACP synthase III · EcFabH

Resolves to

Protein
UniProtP0A6R0UniProt nameFABH_ECOLI
Gene
NCBI Gene946003GenBank145898
Pharmacology
KEGGecj:JW1077
Structure
PDB1EBLPDB1HN9PDB1HND
Drugs

What you can answer from here — as of May 03, 2025

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
29+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Beta-ketoacyl-[acyl-carrier-protein] synthase III, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In