Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

BE0000571ProteinHumansPDHA1

Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex (PubMed:17474719, PubMed:19081061). It is acted on by 3 drugs in DrugBank.

Gene name
PDHA1
UniProtKB entry
P08559Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
390 residues · 43,295 Da
Also known as
1.2.4.1 · PDHE1-A type I · PHE1A

Resolves to

Protein
UniProtP08559UniProt nameODPA_HUMAN
Gene
HGNCHGNC:8806NCBI Gene5160GenBank387009GeneCardsPDHA1
Pharmacology
KEGGhsa:5160
Structure
PDB1NI4PDB2OZLPDB3EXE
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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51+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, how selective are they, and which programs against it are still in active trials?

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