3-oxo-5-alpha-steroid 4-dehydrogenase 2

BE0000585ProteinHumansSRD5A2

Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed:10898110, PubMed:23685396). It is acted on by 10 drugs in DrugBank.

Gene name
SRD5A2
UniProtKB entry
P31213Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
254 residues · 28,407 Da
Also known as
1.3.1.22 · 5 alpha-SR2 · S5AR 2 · SR type 2 · Steroid 5-alpha-reductase 2

Resolves to

Protein
UniProtP31213UniProt nameS5A2_HUMAN
Gene
HGNCHGNC:11285NCBI Gene6716GenBank338469GeneCardsSRD5A2
Pharmacology
IUPHAR/GtoPdb2633KEGGhsa:6716
Structure
PDB7BW1
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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21GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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53+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-oxo-5-alpha-steroid 4-dehydrogenase 2, how selective are they, and which programs against it are still in active trials?

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