Malate dehydrogenase, cytoplasmic

BE0000589ProteinHumansMDH1

Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). It is acted on by 3 drugs in DrugBank.

Gene name
MDH1
UniProtKB entry
P40925Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
334 residues · 36,426 Da
Also known as
1.1.1.37 · Aromatic alpha-keto acid reductase · Cytosolic malate dehydrogenase · KAR · MDHA

Resolves to

Protein
UniProtP40925UniProt nameMDHC_HUMAN
Gene
HGNCHGNC:6970NCBI Gene4190GenBank1255604GeneCardsMDH1
Pharmacology
KEGGhsa:4190
Structure
PDB7RM9PDB7RRL
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Malate dehydrogenase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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