Dihydroorotate dehydrogenase (quinone), mitochondrial

BE0000612ProteinPlasmodium falciparum (isolate 3D7)

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. It is acted on by 16 drugs in DrugBank.

UniProtKB entry
Q08210Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
569 residues · 65,558 Da
Also known as
1.3.5.2 · DHOdehase · Dihydroorotate oxidase

Resolves to

Protein
UniProtQ08210UniProt namePYRD_PLAF7
Gene
NCBI Gene3885966GenBank46362265
Pharmacology
KEGGpfa:PFF0160c
Structure
PDB1TV5PDB3I65PDB3I68
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydroorotate dehydrogenase (quinone), mitochondrial, how selective are they, and which programs against it are still in active trials?

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