Plumbagin

DB17048InvestigationalSmall molecule

Plumbagin is a compound investigated for its anticancer activity. It has been found that it inactivates the Akt/NF-kB, MMP-9 and VEGF pathways.

Chemical structure of Plumbagin
Formula / weight
C11H8O3 · 188.182 g/mol (avg)
Also known as
5-hydroxy-2-methyl-1,4-naphthalenedione
Code names
NSC-236613 · NSC-688284 · PCUR-101

Resolves to

Compound
UNIIYAS4TBQ4OQCAS481-42-5ChEMBLCHEMBL295316ChEBI8273KEGGC10387
Structure
InChIKeyVCMMXZQDRFWYSE-UHFFFAOYSA-NSMILESCC1=CC(=O)C2=C(O)C=CC=C2C1=O
Targets
Q08210Dihydroorotate dehydrogenase (quinone), mitochondrial

What you can answer from here — as of April 23, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
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402Drug interactionsStructured to mechanism, not free text
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2Clinical trialsPhase, status and sponsor resolved per trial
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2+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Plumbagin, and which of those have an active Phase 3 trial?

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