Tyrosine 3-monooxygenase

BE0000614ProteinHumansTH

Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. It is acted on by 8 drugs in DrugBank.

Gene name
TH
UniProtKB entry
P07101Swiss-Prot
Cellular location
Cytoplasm, perinuclear region
Residues / weight
528 residues · 58,600 Da
Also known as
1.14.16.2 · TH · TYH · Tyrosine 3-hydroxylase

Resolves to

Protein
UniProtP07101UniProt nameTY3H_HUMAN
Gene
HGNCHGNC:11782NCBI Gene7054GenBank37127GeneCardsTH
Pharmacology
KEGGhsa:7054
Structure
PDB2XSNPDB4J6SPDB6ZN2
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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32GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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76+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine 3-monooxygenase, how selective are they, and which programs against it are still in active trials?

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