7,8-dihydrobiopterin

DB04400ExperimentalSmall molecule

7,8-Dihydrobiopterin is an inhibitor of the enzyme dihydroneopterin aldolase (DHNA), which catalyzes the conversion of 7,8-Dihydrobiopterin to 6-hydroxymethyl-7,8-dihydropterin and glycolaldehyde.

Mechanism: Pharmacologically active on Nitric oxide synthase, inducible and Tyrosine 3-monooxygenase
Curator reviewed
Formula / weight: C₉H₁₃N₅O₃ · 239.2312 g/mol (avg)
Also known as: Dihydrobiopterin · q-BH2 · Quinonoid dihydrobiopterin
Code names: HBL

Resolves to

Compound

UNIIAYP47DS84PCAS6779-87-9ChEBI43029PubChem119055

Structure

InChIKeyFEMXZDUTFRTWPE-DZSWIPIPSA-NSMILESC[C@H](O)[C@H](O)C1=NC2=C(NC1)NC(N)=NC2=O

Targets

P35228NOS2P07101TH P00439PAHQ01782PTR1P61457PCBD1P56740folB

What you can answer from here — as of September 12, 2026

6Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with 7,8-dihydrobiopterin, and which of those have an active Phase 3 trial?

Answer this in Biopharma OS Sign in to your account

Create a free account or log in to explore the full data card.

Create Account