NADPH-dependent nitroreductase NfsA

BE0000621ProteinEscherichia coli (strain K12)nfsA

Catalyzes the reduction of nitroaromatic compounds using NADPH. It is acted on by 2 drugs in DrugBank.

Gene name
nfsA
UniProtKB entry
P17117Swiss-Prot
Residues / weight
240 residues · 26,800 Da
Also known as
1.-.-.- · 1.7.1.- · mda18 · mdaA · Modulator of drug activity A

Resolves to

Protein
UniProtP17117UniProt nameNFSA_ECOLI
Gene
NCBI Gene945483GenBank609324
Pharmacology
KEGGecj:JW0835
Structure
PDB1F5V
Drugs

What you can answer from here — as of September 08, 2026

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADPH-dependent nitroreductase NfsA, how selective are they, and which programs against it are still in active trials?

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