Nitrofurantoin

DB00698ApprovedInvestigationalVet approvedSmall moleculeAnti-Infective Agents, UrinaryNitrofuran Antibacterial

Nitrofurantoin is an antibiotic used to treat urinary tract infections. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.

Chemical structure of Nitrofurantoin
Mechanism
Curator reviewed · 1 reference
Primary indication
Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.Curator reviewed · 2 structured indications
Formula / weight
C8H6N4O5 · 238.159 g/mol (avg)
First approval
Canada, 1998 · United States, 1953
Also known as
5-Nitrofurantoin · Nitrofurantoin macrocrystal · Nitrofurantoin macrocrystalline
Code names
NSC-2107 · NSC-44150 · USAF EA-2
Brand names
  • Furadantin
  • Macrobid
  • Macrodantin

Resolves to

Compound
UNII927AH8112LCAS67-20-9ChEMBLCHEMBL572ChEBI71415PubChem6604200KEGGD00439
Clinical / RWD
RxNorm235559ATCJ01XE01ATCJ01XE51PharmGKBPA450640
Structure
InChIKeyNXFQHRVNIOXGAQ-YCRREMRBSA-NSMILES[O-][N+](=O)C1=CC=C(O1)\C=N\N1CC(=O)NC1=O
Targets
P52647ydbKP17117nfsAP0A7R5rpsJ
Transporters
Q9UNQ0ABCG2O95342ABCB11P08183ABCB1Q92887ABCC2

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
4TransportersSubstrate / inhibitor direction, not just membership
Listed above
1,431Drug interactionsStructured to mechanism, not free text
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62Clinical trialsPhase, status and sponsor resolved per trial
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2Structured indicationsCondition, population, route and combination as fields, not prose
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10ContraindicationsEach with its own population and attribute set
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588Marketed productsAcross 10 countries and 135 labellers
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2ATC codesIncluding every combination product, plus 20 drug categories
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25+ReferencesStructured and connected to the statements they support
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