Hydroxycarboxylic acid receptor 2

BE0000635ProteinHumansHCAR2

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. It is acted on by 10 drugs in DrugBank.

Gene name
HCAR2
UniProtKB entry
Q8TDS4Swiss-Prot
Cellular location
Cell membrane
Residues / weight
363 residues · 41,849 Da
Also known as
G protein-coupled receptor 109A · G protein-coupled receptor HM74A · GPR109A · HCA2 · HM74A

Resolves to

Protein
UniProtQ8TDS4UniProt nameHCAR2_HUMAN
Gene
HGNCHGNC:24827NCBI Gene338442GenBank28975188GeneCardsHCAR2
Pharmacology
IUPHAR/GtoPdb312KEGGhsa:338442
Structure
PDB7XK2PDB7ZL9PDB7ZLY
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hydroxycarboxylic acid receptor 2, how selective are they, and which programs against it are still in active trials?

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