Interferon alpha/beta receptor 1

BE0000661ProteinHumansIFNAR1

Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461, PubMed:21854986, PubMed:24075985, PubMed:31270247, PubMed:33252644, PubMed:35442418, PubMed:7813427). It is acted on by 14 drugs in DrugBank.

Gene name
IFNAR1
UniProtKB entry
P17181Swiss-Prot
Cellular location
Cell membrane
Residues / weight
557 residues · 63,525 Da
Also known as
CRF2-1 · Cytokine receptor class-II member 1 · Cytokine receptor family 2 member 1 · IFN-alpha/beta receptor 1 · IFN-R-1

Resolves to

Protein
UniProtP17181UniProt nameINAR1_HUMAN
Gene
HGNCHGNC:5432NCBI Gene3454GenBank306914GeneCardsIFNAR1
Pharmacology
IUPHAR/GtoPdb1723KEGGhsa:3454
Structure
PDB3S98PDB3SE3PDB3SE4
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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55+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interferon alpha/beta receptor 1, how selective are they, and which programs against it are still in active trials?

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