Alanine aminotransferase 1

BE0000667ProteinHumansGPT

Pyridoxal enzyme tha catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate (PubMed:11863375). It is acted on by 4 drugs in DrugBank.

Gene name
GPT
UniProtKB entry
P24298Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
496 residues · 54,636 Da
Also known as
2.6.1.2 · AAT1 · ALT1 · Glutamate pyruvate transaminase · Glutamate pyruvate transaminase 1

Resolves to

Protein
UniProtP24298UniProt nameALAT1_HUMAN
Gene
HGNCHGNC:4552NCBI Gene2875GenBank1763096GeneCardsGPT
Pharmacology
KEGGhsa:2875
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alanine aminotransferase 1, how selective are they, and which programs against it are still in active trials?

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