Pyruvate carboxylase, mitochondrial

BE0000698ProteinHumansPC

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. It is acted on by 6 drugs in DrugBank.

Gene name
PC
UniProtKB entry
P11498Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
1,178 residues · 129,633 Da
Also known as
6.4.1.1 · PCB · Pyruvic carboxylase

Resolves to

Protein
UniProtP11498UniProt namePYC_HUMAN
Gene
HGNCHGNC:8636NCBI Gene5091GenBank458236GeneCardsPC
Pharmacology
IUPHAR/GtoPdb1262KEGGhsa:5091
Structure
PDB3BG3PDB3BG9PDB7WTA
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyruvate carboxylase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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