Folylpolyglutamate synthase, mitochondrial

BE0000700ProteinHumansFPGS

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved... It is acted on by 4 drugs in DrugBank.

Gene name
FPGS
UniProtKB entry
Q05932Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
587 residues · 64,609 Da
Also known as
6.3.2.17 · Folylpoly-gamma-glutamate synthetase · FPGS · Tetrahydrofolate synthase · Tetrahydrofolylpolyglutamate synthase

Resolves to

Protein
UniProtQ05932UniProt nameFOLC_HUMAN
Gene
HGNCHGNC:3824NCBI Gene2356GenBank292029GeneCardsFPGS
Pharmacology
KEGGhsa:2356
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Folylpolyglutamate synthase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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