Interferon gamma receptor 1

BE0000711ProteinHumansIFNGR1

Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). It is acted on by 2 drugs in DrugBank.

Gene name
IFNGR1
UniProtKB entry
P15260Swiss-Prot
Cellular location
Cell membrane
Residues / weight
489 residues · 54,404 Da
Also known as
CDw119 · IFN-gamma receptor 1 · IFN-gamma-R-alpha · IFN-gamma-R1 · Interferon gamma receptor alpha-chain

Resolves to

Protein
UniProtP15260UniProt nameINGR1_HUMAN
Gene
HGNCHGNC:5439NCBI Gene3459GenBank306915GeneCardsIFNGR1
Pharmacology
KEGGhsa:3459
Structure
PDB1FG9PDB1FYHPDB1JRH
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interferon gamma receptor 1, how selective are they, and which programs against it are still in active trials?

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