Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

BE0000720ProteinHumansGAPDHS

Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). It is acted on by 9 drugs in DrugBank.

Gene name
GAPDHS
UniProtKB entry
O14556Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
408 residues · 44,501 Da
Also known as
1.2.1.12 · GAPD2 · GAPDH-2 · GAPDH2 · GAPDS

Resolves to

Protein
UniProtO14556UniProt nameG3PT_HUMAN
Gene
HGNCHGNC:24864NCBI Gene26330GenBank3046742GeneCardsGAPDHS
Pharmacology
KEGGhsa:26330
Structure
PDB3H9EPDB3PFWPDB5C7L
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glyceraldehyde-3-phosphate dehydrogenase, testis-specific, how selective are they, and which programs against it are still in active trials?

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