Methionine synthase reductase

BE0000763ProteinHumansMTRR

Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin (PubMed:17892308). It is acted on by 2 drugs in DrugBank.

Gene name
MTRR
UniProtKB entry
Q9UBK8Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
698 residues · 77,673 Da
Also known as
1.16.1.8 · AqCbl reductase · Aquacobalamin reductase · MSR

Resolves to

Protein
UniProtQ9UBK8UniProt nameMTRR_HUMAN
Gene
HGNCHGNC:7473NCBI Gene4552GenBank6572540GeneCardsMTRR
Pharmacology
KEGGhsa:4552
Structure
PDB2QTLPDB2QTZ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methionine synthase reductase, how selective are they, and which programs against it are still in active trials?

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