Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

BE0000771ProteinHumansIDH3G

Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. It is acted on by 4 drugs in DrugBank.

Gene name
IDH3G
UniProtKB entry
P51553Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
393 residues · 42,794 Da
Also known as
Isocitric dehydrogenase subunit gamma · NAD(+)-specific ICDH subunit gamma

Resolves to

Protein
UniProtP51553UniProt nameIDH3G_HUMAN
Gene
HGNCHGNC:5386NCBI Gene3421GenBank1167849GeneCardsIDH3G
Pharmacology
KEGGhsa:3421
Structure
PDB5GREPDB5GRFPDB5GRH
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, how selective are they, and which programs against it are still in active trials?

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