Activated CDC42 kinase 1

BE0000772ProteinHumansTNK2

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. It is acted on by 7 drugs in DrugBank.

Gene name
TNK2
UniProtKB entry
Q07912Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,038 residues · 114,568 Da
Also known as
2.7.10.2 · 2.7.11.1 · ACK-1 · ACK1 · Tyrosine kinase non-receptor protein 2

Resolves to

Protein
UniProtQ07912UniProt nameACK1_HUMAN
Gene
HGNCHGNC:19297NCBI Gene10188GenBank8850245GeneCardsTNK2
Pharmacology
IUPHAR/GtoPdb2246KEGGhsa:10188
Structure
PDB1CF4PDB1U46PDB1U4D
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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21GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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47+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Activated CDC42 kinase 1, how selective are they, and which programs against it are still in active trials?

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