Heparin cofactor 2

BE0000775ProteinHumansSERPIND1

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. It is acted on by 9 drugs in DrugBank.

Gene name
SERPIND1
UniProtKB entry
P05546Swiss-Prot
Residues / weight
499 residues · 57,070 Da
Also known as
HC-II · HCF2 · Heparin cofactor II · HLS2 · Protease inhibitor leuserpin-2

Resolves to

Protein
UniProtP05546UniProt nameHEP2_HUMAN
Gene
HGNCHGNC:4838NCBI Gene3053GenBank183910GeneCardsSERPIND1
Pharmacology
KEGGhsa:3053
Structure
PDB1JMJPDB1JMOPDB2NAT
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Heparin cofactor 2, how selective are they, and which programs against it are still in active trials?

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