Choline kinase alpha

BE0000784ProteinHumansCHKA

Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis (PubMed:17007874, PubMed:19915674, PubMed:23416529, PubMed:34077757). It is acted on by 4 drugs in DrugBank.

Gene name
CHKA
UniProtKB entry
P35790Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
457 residues · 52,249 Da
Also known as
2.7.1.32 · CHETK-alpha · CHK · CK · CKI

Resolves to

Protein
UniProtP35790UniProt nameCHKA_HUMAN
Gene
HGNCHGNC:1937NCBI Gene1119GenBank219541GeneCardsCHKA
Pharmacology
KEGGhsa:1119
Structure
PDB2CKOPDB2CKPPDB2CKQ
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Choline kinase alpha, how selective are they, and which programs against it are still in active trials?

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