Large neutral amino acids transporter small subunit 2

BE0000789ProteinHumansSLC7A8

Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. It is acted on by 6 drugs in DrugBank.

Gene name
SLC7A8
UniProtKB entry
Q9UHI5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
535 residues · 58,381 Da
Also known as
hLAT2 · L-type amino acid transporter 2 · LAT2 · Solute carrier family 7 member 8

Resolves to

Protein
UniProtQ9UHI5UniProt nameLAT2_HUMAN
Gene
HGNCHGNC:11066NCBI Gene23428GenBank6642960GeneCardsSLC7A8
Pharmacology
KEGGhsa:23428
Structure
PDB7B00PDB7CMHPDB7CMI
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Large neutral amino acids transporter small subunit 2, how selective are they, and which programs against it are still in active trials?

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