Floretyrosine F 18 is a fluorine-18-labeled tyrosine derivative and LAT substrate, indicated with PET to differentiate recurrent or progressive glioma from treatment-related change in adults and pediatric patients 1 month and older. Floretyrosine F 18 is a radiolabeled derivative of the amino acid tyrosine that serves as a positron emission tomography (PET) imaging agent for glioma.
- Mechanism
- Curator reviewed · 4 references
Floretyrosine F 18 is a radiolabeled derivative of tyrosine and a substrate for the large neutral amino acid transporters 1 and 2 (LAT). LAT is a sodium-independent exchanger that transports large neutral amino acids, such as tyrosine and phenylalanine, across cell membranes, and it is highly expressed in the blood-brain barrier and glioma tumor tissue. Floretyrosine F 18 accumulates in cells that express LAT on their surface. Fluorine-18 is a positron-emitting radionuclide that enables PET.
- Primary indication
- Floretyrosine F 18 is indicated for use with positron emission tomography (PET) to differentiate recurrent or progressive glioma from treatment-related change, in conjunction with other diagnostic evaluations, in adults and pediatric patients 1 month of...Curator reviewed · 2 structured indications
- Formula / weight
- C11H14FNO3 · 226.238 g/mol (avg)
- First approval
- United States, 2026
- Also known as
- 18F-FET · Floretyrosine F18 · FLUOROETHYL-L-TYROSINE (18F) · O-(2-[18F]Fluoroethyl)-L-tyrosine · O-(2-FLUOROETHYL)-L-TYROSINE F-18
- Code names
- FET F-18
Resolves to
QZZYPHBVOQMBAT-LRAGLOQXSA-NSMILESN[C@@H](CC1=CC=C(OCC[18F])C=C1)C(O)=OWhat you can answer from here — as of October 29, 2026
Which drugs share a target with Floretyrosine F 18, and which of those have an active Phase 3 trial?
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