DNA gyrase subunit B

BE0000799ProteinEscherichia coli (strain K12)gyrB

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed:12051842, PubMed:12051843, PubMed:1323022, PubMed:18642932, PubMed:186775, PubMed:19060136, PubMed:19965760, PubMed:20356737, PubMed:20675723, PubMed:22457353, PubMed:23294697, PubMed:23352267, PubMed:24386374, PubMed:25202966, PubMed:25849408, PubMed:3031051,... It is acted on by 10 drugs in DrugBank.

Gene name
gyrB
UniProtKB entry
P0AES6Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
804 residues · 89,949 Da
Also known as
5.6.2.2 · 5.99.1.3 · acrB · cou · himB

Resolves to

Protein
UniProtP0AES6UniProt nameGYRB_ECOLI
Gene
NCBI Gene948211GenBank41646
Pharmacology
KEGGecj:JW5625
Structure
PDB1AJ6PDB1EI1PDB1KZN
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA gyrase subunit B, how selective are they, and which programs against it are still in active trials?

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