3-oxoacyl-[acyl-carrier-protein] synthase 2

BE0000800ProteinEscherichia coli (strain K12)fabF

Involved in the type II fatty acid elongation cycle (PubMed:6988423, PubMed:9013860). It is acted on by 4 drugs in DrugBank.

Gene name
fabF
UniProtKB entry
P0AAI5Swiss-Prot
Residues / weight
413 residues · 43,045 Da
Also known as
2.3.1.179 · 3-oxoacyl-[acyl-carrier-protein] synthase II · Beta-ketoacyl-ACP synthase II · fabJ · KAS II

Resolves to

Protein
UniProtP0AAI5UniProt nameFABF_ECOLI
Gene
NCBI Gene946665GenBank572680
Pharmacology
KEGGecj:JW1081
Structure
PDB1B3NPDB1KASPDB2GFV
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-oxoacyl-[acyl-carrier-protein] synthase 2, how selective are they, and which programs against it are still in active trials?

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