3-oxoacyl-[acyl-carrier-protein] synthase 1

BE0000801ProteinEscherichia coli (strain K12)fabB

Involved in the type II fatty acid elongation cycle. It is acted on by 8 drugs in DrugBank.

Gene name
fabB
UniProtKB entry
P0A953Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
406 residues · 42,613 Da
Also known as
2.3.1.41 · 3-oxoacyl-[acyl-carrier-protein] synthase I · Beta-ketoacyl-ACP synthase I · fabC · KAS I

Resolves to

Protein
UniProtP0A953UniProt nameFABB_ECOLI
Gene
NCBI Gene946799GenBank145884
Pharmacology
KEGGecj:JW2320
Structure
PDB1DD8PDB1EK4PDB1F91
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-oxoacyl-[acyl-carrier-protein] synthase 1, how selective are they, and which programs against it are still in active trials?

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