Glutathione S-transferase A3

BE0000809ProteinHumansGSTA3

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. It is acted on by 4 drugs in DrugBank.

Gene name
GSTA3
UniProtKB entry
Q16772Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
222 residues · 25,301 Da
Also known as
2.5.1.18 · Glutathione S-transferase A3-3 · GST class-alpha member 3

Resolves to

Protein
UniProtQ16772UniProt nameGSTA3_HUMAN
Gene
HGNCHGNC:4628NCBI Gene2940GenBank951352GeneCardsGSTA3
Pharmacology
KEGGhsa:2940
Structure
PDB1TDIPDB2VCV
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione S-transferase A3, how selective are they, and which programs against it are still in active trials?

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