Merbromin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Merbromin is a topical antiseptic indicated in the disinfection of lacerations.

Generic Name
Merbromin
DrugBank Accession Number
DB13392
Background

Mercurochrome is a trade name of merbromin commonly used as a topical first-aid antiseptic agent. It is an organomercuric disodium salt compound and a fluorescein that is available in many countries, except Switzerland, France, Germany, and the United States where the drug was withdrawn from market due to the possibility of mercury poisoning.

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 750.65
Monoisotopic: 749.818928236
Chemical Formula
C20H8Br2HgNa2O6
Synonyms
  • Merbromin
  • Merbromina
  • Merbromine
  • Merbrominum
  • Mercurochrome

Pharmacology

Indication

Not Available

Pharmacology
Accelerate your drug discovery research with the industry’s only fully connected ADMET dataset, ideal for:
Machine Learning
Data Science
Drug Discovery
Accelerate your drug discovery research with our fully connected ADMET dataset
Learn more
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
With our commercial data, access important information on dangerous risks, contraindications, and adverse effects.
Learn more
Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
Reduce medical errors
and improve treatment outcomes with our comprehensive & structured data on drug adverse effects.
Learn more
Reduce medical errors & improve treatment outcomes with our adverse effects data
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Products
Comprehensive & structured drug product info
From application numbers to product codes, connect different identifiers through our commercial datasets.
Learn more
Easily connect various identifiers back to our datasets
Learn more
International/Other Brands
Mercurochrome
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
ยาน้ำแดง (ซีโต้) ตราเต่าบินSolution2 g/100 mlTopicalบริษัท ปัจจุบันโอสถ จำกัด จำกัด1986-02-27Not applicableThailand flag
ยาแดงSolution2 g/100 mlTopicalห้างหุ้นส่วนจำกัด โรงงานผลิตยาอันอันโอสถ1987-05-26Not applicableThailand flag
ยาแดงSolution2 g/100 mlTopicalบริษัท วิทยาศรม จำกัด1985-01-29Not applicableThailand flag
ยาแดง - ตราโลโล่Solution2 g/100 mlTopicalบริษัท แลชแมน จำกัด จำกัด2001-03-21Not applicableThailand flag
ยาแดง (ตรามงกุฏพญานาคคู่)Solution2 g/100 mlTopicalบริษัท ศิริบัญชา จำกัด จำกัด1987-02-132020-08-27Thailand flag
ยาแดงสหการSolution2 g/100 mlTopicalบริษัท สหการโอสถ (1996) จำกัด จำกัด1996-12-26Not applicableThailand flag

Categories

ATC Codes
D08AK04 — Merbromin
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzopyrans
Sub Class
1-benzopyrans
Direct Parent
Xanthenes
Alternative Parents
Benzoic acids and derivatives / Benzoyl derivatives / Metal aryls / Aryl bromides / Heteroaromatic compounds / Cyclic ketones / Carboxylic acid salts / Oxacyclic compounds / Organic transition metal salts / Organic alkali metal salts
show 5 more
Substituents
Aromatic heteropolycyclic compound / Aryl bromide / Aryl halide / Benzenoid / Benzoic acid or derivatives / Benzoyl / Carboxylic acid derivative / Carboxylic acid salt / Cyclic ketone / Heteroaromatic compound
show 18 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
M0T18YH28D
CAS number
129-16-8
InChI Key
SQFDQLBYJKFDDO-UHFFFAOYSA-K
InChI
InChI=1S/C20H9Br2O5.Hg.2Na.H2O/c21-13-5-11-17(7-15(13)23)27-18-8-16(24)14(22)6-12(18)19(11)9-3-1-2-4-10(9)20(25)26;;;;/h1-7,24H,(H,25,26);;;;1H2/q;3*+1;/p-3
IUPAC Name
disodium [2,7-dibromo-9-(2-carboxylatophenyl)-6-oxido-3-oxo-3H-xanthen-5-yl]mercurol
SMILES
[Na+].[Na+].O[Hg]C1=C([O-])C(Br)=CC2=C1OC1=CC(=O)C(Br)=CC1=C2C1=CC=CC=C1C([O-])=O

References

General References
  1. FDA Thailand Product Information: Mercurochrome (merbromin) topical solution [Link]
KEGG Drug
D00861
PubChem Compound
2724062
PubChem Substance
347829297
ChemSpider
8029248
RxNav
6762
ChEBI
6763
Wikipedia
Merbromin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionTopical2 g
SolutionTopical
SolutionTopical2 g/100 ml
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0844 mg/mLALOGPS
logP3.77ALOGPS
logP3.07ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)3.61ChemAxon
pKa (Strongest Basic)-2ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area109.72 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity142.01 m3·mol-1ChemAxon
Polarizability42.76 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on June 23, 2017 20:41 / Updated on June 02, 2021 20:04