Delta-1-pyrroline-5-carboxylate synthase

BE0000823ProteinHumansALDH18A1

Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. It is acted on by 2 drugs in DrugBank.

Gene name
ALDH18A1
UniProtKB entry
P54886Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
795 residues · 87,302 Da
Also known as
Aldehyde dehydrogenase family 18 member A1 · GSAS · P5CS · PYCS

Resolves to

Protein
UniProtP54886UniProt nameP5CS_HUMAN
Gene
HGNCHGNC:9722NCBI Gene5832GenBank1304314GeneCardsALDH18A1
Pharmacology
KEGGhsa:5832
Structure
PDB2H5G
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Delta-1-pyrroline-5-carboxylate synthase, how selective are they, and which programs against it are still in active trials?

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