Oxytocin receptor

BE0000844ProteinHumansOXTR

G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:11923477, PubMed:22069312, PubMed:32832646, PubMed:35104164,... It is acted on by 13 drugs in DrugBank.

Gene name
OXTR
UniProtKB entry
P30559Swiss-Prot
Cellular location
Cell membrane
Residues / weight
389 residues · 42,771 Da
Also known as
OT-R

Resolves to

Protein
UniProtP30559UniProt nameOXYR_HUMAN
Gene
HGNCHGNC:8529NCBI Gene5021GenBank34765GeneCardsOXTR
Pharmacology
IUPHAR/GtoPdb369KEGGhsa:5021
Structure
PDB6TPKPDB7QVMPDB7RYC
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Oxytocin receptor, how selective are they, and which programs against it are still in active trials?

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