Phenylethanolamine N-methyltransferase

BE0000865ProteinHumansPNMT

Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117). It is acted on by 16 drugs in DrugBank.

Gene name
PNMT
UniProtKB entry
P11086Swiss-Prot
Residues / weight
282 residues · 30,855 Da
Also known as
2.1.1.28 · Noradrenaline N-methyltransferase · PENT · PNMTase

Resolves to

Protein
UniProtP11086UniProt namePNMT_HUMAN
Gene
HGNCHGNC:9160NCBI Gene5409GenBank190142GeneCardsPNMT
Pharmacology
IUPHAR/GtoPdb2496KEGGhsa:5409
Structure
PDB1HNNPDB1N7IPDB1N7J
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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1Pfam domainDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phenylethanolamine N-methyltransferase, how selective are they, and which programs against it are still in active trials?

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