Alpha-synuclein

BE0000878ProteinHumansSNCA

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). It is acted on by 11 drugs in DrugBank.

Gene name
SNCA
UniProtKB entry
P37840Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
140 residues · 14,460 Da
Also known as
NACP · Non-A beta component of AD amyloid · Non-A4 component of amyloid precursor · PARK1

Resolves to

Protein
UniProtP37840UniProt nameSYUA_HUMAN
Gene
HGNCHGNC:11138NCBI Gene6622GenBank437365GeneCardsSNCA
Pharmacology
IUPHAR/GtoPdb3285KEGGhsa:6622
Structure
PDB10XUPDB1XQ8PDB2JN5
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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78GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-synuclein, how selective are they, and which programs against it are still in active trials?

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