Aquaporin-1

BE0000880ProteinHumansAQP1

Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). It is acted on by 6 drugs in DrugBank.

Gene name
AQP1
UniProtKB entry
P29972Swiss-Prot
Cellular location
Cell membrane
Residues / weight
269 residues · 28,526 Da
Also known as
AQP-1 · Aquaporin-CHIP · Channel-like integral membrane protein of 28 kDa · CHIP28 · Urine water channel

Resolves to

Protein
UniProtP29972UniProt nameAQP1_HUMAN
Gene
HGNCHGNC:633NCBI Gene358GenBank180501GeneCardsAQP1
Pharmacology
IUPHAR/GtoPdb688KEGGhsa:358
Structure
PDB1FQYPDB1H6IPDB1IH5
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aquaporin-1, how selective are they, and which programs against it are still in active trials?

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