Sulfotransferase 2A1

BE0000886ProteinHumansSULT2A1

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:20102295, PubMed:21187059, PubMed:2268288, PubMed:29671343, PubMed:7678732, PubMed:7854148). It is acted on by 9 drugs in DrugBank.

Gene name
SULT2A1
UniProtKB entry
Q06520Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
285 residues · 33,780 Da
Also known as
2.8.2.2 · Bile salt sulfotransferase · Dehydroepiandrosterone sulfotransferase · DHEA-ST · DHEA-ST8

Resolves to

Protein
UniProtQ06520UniProt nameST2A1_HUMAN
Gene
HGNCHGNC:11458NCBI Gene6822GenBank306702GeneCardsSULT2A1
Pharmacology
KEGGhsa:6822
Structure
PDB1EFHPDB1J99PDB1OV4
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7Metabolic reactionsDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sulfotransferase 2A1, how selective are they, and which programs against it are still in active trials?

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