Cyclin-dependent kinase 5

BE0000890ProteinHumansCDK5

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. It is acted on by 14 drugs in DrugBank.

Gene name
CDK5
UniProtKB entry
Q00535Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
292 residues · 33,304 Da
Also known as
2.7.11.1 · CDKN5 · Cell division protein kinase 5 · Cyclin-dependent-like kinase 5 · PSSALRE

Resolves to

Protein
UniProtQ00535UniProt nameCDK5_HUMAN
Gene
HGNCHGNC:1774NCBI Gene1020GenBank36621GeneCardsCDK5
Pharmacology
IUPHAR/GtoPdb1977KEGGhsa:1020
Structure
PDB1H4LPDB1UNGPDB1UNH
Drugs

What you can answer from here — as of September 03, 2024

14DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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40GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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79+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclin-dependent kinase 5, how selective are they, and which programs against it are still in active trials?

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