Sepiapterin reductase

BE0000909ProteinHumansSPR

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. It is acted on by 5 drugs in DrugBank.

Gene name
SPR
UniProtKB entry
P35270Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
261 residues · 28,048 Da
Also known as
1.1.1.153 · SPR

Resolves to

Protein
UniProtP35270UniProt nameSPRE_HUMAN
Gene
HGNCHGNC:11257NCBI Gene6697GenBank338021GeneCardsSPR
Pharmacology
IUPHAR/GtoPdb3020KEGGhsa:6697
Structure
PDB1Z6ZPDB4HWKPDB4J7U
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sepiapterin reductase, how selective are they, and which programs against it are still in active trials?

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